The mechanism of action of carboxytherapy in striae treating includes several biochemical processes discount acarbose 25 mg overnight delivery diabetes 2 diet. Carbon dioxide stimulates blood circulation and increases the release of oxygen by means of oxyhemoglobin generic acarbose 50mg without prescription medical definition diabetes type 2, tissues has a powerful incentive to regeneration cheap acarbose 50mg with visa diabetes type 1 unplanned pregnancy. The subcutaneous tissues after a few sessions of carboxytherapy are restructured: fibrous commissures are destroyed, homogeneity of supporting tissues are achieved. In addition, carboxytherapy activates the synthesis of collagenase, elastin and hyaluronic acid by stimulating of fibroblast function. On this mechanism it is based most pronounced aesthetic result of carboxytherapy increase of skin elasticity. Opinions about carboxytherapy of patients with striae are positive in 98% of cases. Carboxytherapy improves the state of various types of scars after 1-2 procedures: acne, less traumatic and postoperative. Regime of administration: for fresh striae requires from 2 to 4 sessions of carboxytherapy with a break for a week; for striae, that more than a year, it takes 3-4 sessions carried in a month, the course of 8-12 sessions, the depth of administration is 5-6 mm. The first few seconds after a session is possible burning and heat sensation, itchiness in the place of injection. In conclusions сarboxytherapy is a method of aesthetic treatment based on an effective and non-toxic naturally occurring metabolite of the body which is becoming popular day by day and used for the treatment of striae and other skin diseases. Neuroprotective and geroprotective effects of estrogen, mesenchymal stem cells, adipose tissue, placental extract were shown. The aim of study was to investigate the neuroprotective effect of placental factors. To correctly compare the effectiveness of the test substances is necessary to select suitable concentrations.

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In correlation studies buy 25 mg acarbose with mastercard metabolic disease gout, the units of inves- tigation are usually whole populations (e purchase acarbose 50 mg diabetes mellitus physiology. Confounding is a form of bias individual exposure is not documented generic 25mg acarbose otc diabetes prevention books, which that occurs when the relationship with disease is renders this kind of study more prone to con- made to appear stronger or weaker than it truly is founding. Tese types of study tors have been minimized in an individual study, generally arise from a suspicion, based on clinical consideration is given to several aspects of design experience, that the concurrence of two events — and analysis as described in the report of the that is, a particular exposure and occurrence of study. For example, when suspicion of carcino- a cancer — has happened rather more frequently genicity arises largely from a single small study, than would be expected by chance. Case reports careful consideration is given when interpreting and case series usually lack complete ascertain- subsequent studies that included these data in an ment of cases in any population, defnition or enlarged population. Most of these considera- enumeration of the population at risk and esti- tions apply equally to case–control, cohort and mation of the expected number of cases in the correlation studies. Cases of disease in the case–control and cohort studies, however, these study population should have been identifed in types of study may add materially to the judge- a way that was independent of the exposure of ment that a causal relationship exists. Tey may, in some instances, other variables that can infuence the risk of dis- strengthen inferences drawn from studies of ease and may have been related to the exposure cancer itself. Potential confounding by such vari- ables should have been dealt with either in the (b) Quality of studies considered design of the study, such as by matching, or in the analysis, by statistical adjustment. In cohort It is necessary to take into account the pos- studies, comparisons with local rates of disease sible roles of bias, confounding and chance in may or may not be more appropriate than those the interpretation of epidemiological studies. At the very least, they should have ured co-variates that may difer among studies. In a cohort study, data on all pooled analysis that is pertinent to a particular cancer sites and all causes of death should have Monograph (see Part A, Section 4). Additionally, been given, to reveal the possibility of reporting as a means of gaining insight from the results of bias.

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O. Gambal. University of Texas Southwestern Medical Center.